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Avandia From Wikipedia

EU EMA:Link, US FDA:link Pregnancy cat. B3(AU) C(US) Legal status POM (UK) ℞-only (US) Routes Oral  Y(what is this?)  (verify) Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Annual sales peaked at approx $2.5bn in 2006, but declined after reports of adverse effects. The drug's patent expires in 2012.[1] Some reports have suggested that rosiglitazone is associated with a statistically significant risk of heart attacks, but other reports have disagreed, and the controversy has not been resolved. Concern about adverse effects has reduced the use of rosiglitazone despite its sustained effects on glycemic control.[2] The drug is currently the subject of many lawsuits against GSK. Over 13,000 have been brought against the company due to the drug. [3] As of July 2010, GSK has agreed to settlements on more that 11,500 of these suits. The drug is controversial in the U.S. Food and Drug Administration. Some reviewers concluded that rosiglitazone caused more deaths than pioglitazone (Actos) and recommended that rosiglitazone be taken off the market, but an F.D.A. panel disagreed and it remains on the market in the U.S.[4] Contents 1 Pharmacology 2 Side-effects and contraindications 2.1 Heart disease 2.2 Stroke 2.3 Bone fractures 2.4 Eye damage 2.5 Hepatotoxicity 3 Sales 4 Lawsuits 5 US Government Investigation 6 Controversy and response 6.1 PCRM Lawsuit 7 References 8 External links // [edit] Pharmacology Rosiglitazone is a member of the thiazolidinedione class of drugs. Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferato · Read more about Avandia

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